ABSTRACT

The lack of accuracy and penetration significantly hinder the clinical use of microwave (MW) thermotherapy. To
address this issue, we propose a microwave thermal supercharging system (MTSS) featuring a miniature meta
surface grid waveguide aperture antenna and MW-chaperone GaMOF-Co/Ni nanotopographies (GCN NTs) as
MW absorbing materials. The meta surface grid waveguide aperture antenna, designed with filled meta surfaces,
offers a reduced size, constrained MW beams, and focused energy for precise tumor MW thermotherapy. The
MW-chaperone GCN NTs with multiple heterogeneous interfaces and magnetic structures were developed to
enhance the dielectric and magnetic loss characteristics and improve MW absorption at medical frequencies
(>90 %). Enhancing MW energy delivery to boost thermal conversion efficiency through meta surface grid
waveguide aperture antenna innovation is analogous to increasing the air pressure in an engine’s intake mani
fold. This system significantly improved the effectiveness of MW thermotherapy, achieving a 93 % inhibition and
100 % survival in vivo under clinically simulated deep-tissue conditions. By transforming microwave fields into
programmable, tissue-specific therapeutic heat, this MTSS serves as a modular and device-compatible platform
that redefines noninvasive oncology as a precision, energy-directed strategy with scalable clinical potential.